Clinical efficacy of dexmedetomidine combined with lidocaine for femoral and sciatic nerve blocks in dogs undergoing stifle surgery

Objective To evaluate the effects of dexmedetomidine administered perineurally or intramuscularly (IM) on sensory, motor function and postoperative analgesia produced by lidocaine for sciatic and femoral nerve blocks in dogs undergoing unilateral tibial tuberosity advancement surgery. Study design Prospective, blinded, clinical study. Animals A group of 30 dogs. Methods Dogs were anaesthetized with acepromazine, propofol and isoflurane in oxygen/air. Electrolocationguided femoral and sciatic nerve blocks were performed: group L, 0.15 mL kg(-1) 2% lidocaine (n = 10); group lidocaine and 0.15 mu g kg(-1) dexmedetomidine perineurally (n = 10); group LDsys, lidocaine and 0.3 mu g kg(-1) dexmedetomidine IM (n = 10). After anaesthesia, sensory blockade was evaluated by response to forceps pinch on skin innervated by the saphenous/femoral, common fibular and tibial nerves. Motor blockade was evaluated by observing the ability to walk and proprioception. Analgesia was monitored with Short Form of Glasgow Composite Pain Scale for up to 4 hours after extubation. Methadone IM was administered as rescue analgesia. Data were analysed by linear mixed effect models and Kaplan-Meier test (p < 0.05). Results Median duration of the sensory blockade for all nerves was longer (p < 0.001) for group LDloc than for groups L and LDsys and was longer (p = 0.0011) for group LDsys than for group L. Proprioception returned later (p < 0.001) for group LDsys [ 285 (221-328) minutes] compared with group L [160 (134-179) minutes] or LDsys [195 (162-257) minutes]. Return of the ability to walk was similar among all groups. Dogs in group ID(loc )required postoperative rescue analgesia later (p = 0.001) than dogs in groups LDsys and L. Conclusions and clinical relevance Dexmedetomidine administered perineurally with lidocaine prolonged sensory blockade and analgesia during the immediate postoperative period. Systemic dexmedetomidine also prolonged the sensory blockade of perineural lidocaine.