Who watches the watchmen? RNAi pathway-derived ribosomal small RNAs burgeon in absence of piRNAs

被引：1

作者：

Ramakrishna, Navin B. ^{[1
,2
]}

Miska, Eric A. ^{[1
,2
,3
]}

机构：

[1] Univ Cambridge, Wellcome CRUK Gurdon Inst, Tennis Court Rd, Cambridge, England

[2] Univ Cambridge, Dept Genet, Downing St, Cambridge, England

[3] Wellcome Sanger Inst, Wellcome Trust Genome Campus, Cambridge, England

来源：

DEVELOPMENTAL CELL | 2021年 / 56卷 / 16期

关键词：

D O I：

10.1016/j.devcel.2021.08.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Instead of causing immediate sterility, loss of the C. elegans PIWI protein PRG-1 leads to accumulated infertility after tens of generations. In this issue of Developmental Cell, Wahba et al. show that this correlates with aberrant RNA interference pathway-dependent feed forward amplification of ribosomal siRNAs-the proposed accumulative sterility factor.

引用

页码：2269 / 2270

页数：2