Co-precipitation of mefenamic acid-polyvinylpyrrolidone K30 composites using Gas Anti-Solvent

In this study, composites of mefenamic acid (MEF) and polyvinylpyrrolidone K30 (PVP K30, MW similar to 40,000) were synthesized by applying the Gas Anti-Solvent (GAS) technique. It was found that an increase in drug-to-polymer ratio resulted in a higher % drug content. However, temperature and solution concentration had no significant effect on the % drug content when the amount, of polymer in the solution was lower than or equal to that of the drug. The dissolution rate of the MEF PVP composites was found to be 7 times and 3 times greater than those of the unprocessed MEF and physical mixture, respectively. (c) 2016 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.