Nodal Anaplastic Large-Cell Lymphoma ALK-1-with CD30+Cutaneous Lymphoproliferation Treated with Mistletoe: Spontaneous Remission or Treatment Response?

被引：8
|
作者：
Kameda, G. [1 ]
Kempf, W. [2 ]
Oschlies, I. [3 ,4 ]
Michael, K. [1 ]
Seifert, G. [5 ]
Laengler, A. [1 ,6 ]
机构：
[1] Gemeinschaftskrankenhaus, Abt Kinder & Jugendmed, Dept Integrat Pediat & Adolescent Med, D-58313 Herdecke, Germany
[2] Univ Zurich, Dept Dermatol, CH-8006 Zurich, Switzerland
[3] Univ Kiel, Dept Pathol, Hematopathol Sect, D-2300 Kiel, Germany
[4] Univ Kiel, Lymph Node Registry, D-2300 Kiel, Germany
[5] Univ Berlin Charite, Dept Pediat Oncol & Hematol, Berlin, Germany
[6] Ctr Integrat Med, Fac Hlth, Sch Med, Witten, Germany
来源：
KLINISCHE PADIATRIE | 2011年 / 223卷 / 06期
关键词：
lymphomatoid papulosis; primary cutaneous CD30+T-cell lymphoproliferation; mistletoe; complementary and alternativ medicine; PAPULOSIS;
D O I：
10.1055/s-0031-1285914
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
A 12-year old girl presented with general weakness and weight loss, a localised cervical lymph node enlargement and cutaneous lesions compatible with lymphomatoid papulosis (LyP). Biopsies from lymph node and skin revealed a histological diagnosis of nodal large cell ALK-1- anaplastic lymphoma (ALCL) with a synchronous CD30+ cutaneous lymphoproliferation consistent with lymphomatoid papulosis (LyP). The girl was treated with mistletoe (MT) as monotherapy. Within 1 week after initiation of MT-treatment the skin lesions and lymph node enlargement improved. Under continuing MT-therapy 30 months after diagnosis the patient is still in complete remission. It is not possible to know whether this was a rare case of spontaneous remission of the nodal and skin-manifestations of this CD30+ T-cell lymphoproliferation or whether the observed effect was a specific therapeutic response to MT-treatment.
引用
收藏
页码：364 / 367
页数：4
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