Clinical study on thymoma: Assessment of prognostic factors

被引:0
|
作者
Sassa, K
Mizushima, Y
Kusajima, Y
Sugiyama, S
Noto, H
Kobayashi, M
机构
[1] TOYAMA MED & PHARMACEUT UNIV, DEPT INTERNAL MED 1, TOYAMA 93001, JAPAN
[2] TOYAMA MED & PHARMACEUT UNIV, DEPT SURG 1, TOYAMA 93001, JAPAN
[3] TOYAMA CIV HOSP, DEPT THORAC SURG, TOYAMA 939, JAPAN
[4] TOYAMA PREFECTURAL CENT HOSP, DEPT CARDIOVASC & THORAC SURG, TOYAMA 930, JAPAN
关键词
mediastinal tumor; thymoma; prognostic factors;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In order to define the clinical features of thymoma, we reviewed 51 thymoma patients in our departments from 1980 to 1995. Of 146 mediastinal tumors, 51 (35%) had thymoma, the most frequent tumor, and 21 (14%) had neurinoma. Twenty-one patients had non-invasive thymoma (Masaoka staging = stage I) and 30 had invasive thymoma (stages II-IV). In the non-invasive group, the male to female ratio was 0.8 (9/12) and the majority were of mixed histologic type (13/21 = 62%). Conversely, in the invasive group, the male to female ratio was 1.7 (19/11), and the occurrence of the epithelial type (12 = 40%) was as frequent as the mixed type (13 = 43%). Patients with non-invasive thymoma were all treated with surgery only, and those with invasive thymona were treated with multimodalities except for one. The 5-year survival rate was 100% for the non-invasive group, and 67% for the invasive group. Patients with accompanying myasthenia gravis (MG) showed a better prognosis than the non-MG patients (P < 0.05). The lymphocytic type also showed a better prognosis than the epithelial type, but this was not statistically significant. The prognosis for patients with thymoma was much better than for those with thymic cancer (n = 9). Thymoma showed a variety of clinical features depending on histologic type and association with myasthenia gravis.
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页码:3895 / 3900
页数:6
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