An integrated genomic characterization of the target of a small molecule identifies a novel cancer dependency

被引:0
|
作者
de Waal, Luc M. [1 ]
Lewis, Tim A. [2 ]
Gechijian, Lara [3 ]
Tsherniak, Aviad [2 ]
Youngsaye, Willmen [2 ]
Rees, Matthew [2 ]
Mikse, Oliver [1 ]
Hickey, Mark [2 ]
Faloon, Patrick [2 ]
Tolliday, Nicola [2 ]
Koehler, Angela [2 ]
Schenone, Monica [2 ]
Wong, Kwok [1 ]
Shamji, Alykhan [2 ]
Munoz, Benito [2 ]
Schreiber, Stuart L. [2 ]
Greulich, Heidi [1 ]
Meyerson, Matthew L. [1 ]
机构
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
[2] Broad Inst Harvard & MIT, Cambridge, MA USA
[3] Wellesley Coll, Wellesley, MA 02181 USA
关键词
D O I
10.1158/1538-7445.AM2014-4596
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4596
引用
收藏
页数:2
相关论文
共 50 条
  • [1] INTEGRATED GENOMIC ANALYSIS IDENTIFIES THE MITOTIC CHECKPOINT AS A NOVEL THERAPEUTIC TARGET IN MEDULLOBLASTOMA
    Harris, Peter
    Venkataraman, Sujatha
    Alimova, Irina
    Birks, Diane
    Cristiano, Brian
    Donson, Andrew
    Foreman, Nicholas
    Vibhakar, Rajeev
    NEURO-ONCOLOGY, 2012, 14 : 88 - 88
  • [2] Interrogative Biology® platform identifies a novel target in the ubiquitin pathway and its utility in cancer is supported by small molecule modulators
    Gesta, Stephane
    Sharma, Shefali
    Sundararajan, Pragalath
    Huang, Mingshu
    Gray, Kayleigh
    Nastke, Maria
    Guven, Arcan
    Diers, Anne
    Kazerounian, Shiva
    Hazarika, Suwagmani
    Grund, Eric M.
    Vishnudas, Vivek K.
    Narain, Niven R.
    Sarangarajan, Rangaprasad
    CANCER RESEARCH, 2020, 80 (16)
  • [3] Integrated genomic analysis of clear-cell ovarian cancer identifies PRKCI as a therapeutic target
    Tsang, Tsun Yee
    Mohapatra, Gayatry
    Itamochi, Hiroaki
    Mok, Samuel C.
    Birrer, Michael J.
    CANCER RESEARCH, 2015, 75
  • [4] Functional genomic screening identifies USP11 as a novel therapeutic target in breast cancer
    Dwane, L.
    O'Connor, A.
    Mulrane, L.
    Klinger, R.
    Dirac, A.
    Jirstrom, K.
    Crown, J.
    Bernards, R.
    Gallagher, W.
    O'Connor, D.
    EUROPEAN JOURNAL OF CANCER, 2016, 61 : S10 - S10
  • [5] Functional genomic screening identifies USP11 as a novel therapeutic target in breast cancer
    O'Connor, Darran P.
    Dwane, Lisa
    O'Connor, Aisling E.
    Dirac, Annette M.
    Bernards, Rene
    Gallagher, William M.
    CANCER RESEARCH, 2015, 75
  • [6] Functional genomic screening identifies USP11 as a novel therapeutic target in breast cancer
    O'Connor, Darran
    Dwane, Lisa
    O'Connor, Aisling
    Bernards, Rene
    Gallagher, William
    CANCER RESEARCH, 2016, 76
  • [7] Functional Genomic Screening Identifies USP11 as a Novel Therapeutic Target in Breast Cancer
    Dwane, L.
    O'Connor, A. E.
    Mulrane, L.
    Dirac, A. M.
    Jirstrom, K.
    Crown, J. P.
    Bernards, R.
    Gallagher, W. M.
    O'Connor, D. P.
    IRISH JOURNAL OF MEDICAL SCIENCE, 2016, 185 : S3 - S4
  • [8] Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma
    Peter S Harris
    Sujatha Venkataraman
    Irina Alimova
    Diane K Birks
    Ilango Balakrishnan
    Brian Cristiano
    Andrew M Donson
    Adrian M Dubuc
    Michael D Taylor
    Nicholas K Foreman
    Philip Reigan
    Rajeev Vibhakar
    Molecular Cancer, 13
  • [9] Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma
    Harris, Peter S.
    Venkataraman, Sujatha
    Alimova, Irina
    Birks, Diane K.
    Balakrishnan, Ilango
    Cristiano, Brian
    Donson, Andrew M.
    Dubuc, Adrian M.
    Taylor, Michael D.
    Foreman, Nicholas K.
    Reigan, Philip
    Vibhakar, Rajeev
    MOLECULAR CANCER, 2014, 13
  • [10] Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells
    Rodgers, Ursula R.
    Lanyon-Hogg, Thomas
    Masumoto, Naoko
    Ritzefeld, Markus
    Burke, Rosemary
    Blagg, Julian
    Magee, Anthony I.
    Tate, Edward W.
    ACS CHEMICAL BIOLOGY, 2016, 11 (12) : 3256 - 3262