Synthesis and Anticancer Activity Assay of Novel Chalcone-Sulfonamide Derivatives

被引：0
|
作者：
Bonakdar, Ahmad Pesaran Seiied [1 ]
Vafaei, Farzane [2 ]
Farokhpour, Mahbobeh [2 ]
Esfahani, Mohammad Hossein Nasr [3 ]
Massah, Ahmad Reza [1 ]
机构：
[1] Islamic Azad Univ, Shahreza Branch, Dept Chem, Shahreza 86145311, Iran
[2] Islamic Azad Univ, Shahreza Branch, Dept Pharm, Shahreza 86145311, Iran
[3] Royan Inst, Isfahan Branch, Tehran, Iran
来源：
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2017年 / 16卷 / 02期
关键词：
Anticancer activity; Chalcone; Sulfonamide; SOLVENT-FREE; EFFICIENT; ANTIBACTERIAL; CATALYST;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Today Cancer remains to be one of the most deadly diseases in the world. Due to the potential anticancer activity of the chalcone and sulfonamide moieties, five novel hybrid compounds containing both structures have been designed and synthesized in 3 steps. The synthesized compounds were established on the basis of IR, H-1 NMR, C-13 NMR spectral data, and elemental analysis and also they were screened for in-vitro anticancer activity on human breast cancer cell line MCF-7. Among them, (E)-2-methoxy-N-(4-methoxyphenyl)-5-(3-(4- nitrophenyl) acryloyl) benzene sulfonamide (4) showed the most potent anticancer activity against MCF-7 cell line.
引用
收藏
页码：565 / 568
页数：4
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