Electrochemical sensors for oxidative stress monitoring

被引：17
|
作者：
Deshpande, Aaditya S. [1 ]
Muraoka, Wayne [2 ]
Andreescu, Silvana [1 ]
机构：
[1] Clarkson Univ, Dept Chem & Biomol Sci, Potsdam, NY 13699 USA
[2] US Army, Inst Surg Res Blood & Shock Resuscitat, Ft Sam Houston, TX 78234 USA
来源：
CURRENT OPINION IN ELECTROCHEMISTRY | 2021年 / 29卷
基金：
美国国家科学基金会;
关键词：
Oxidative stress; ROS/RNS; Nitric oxide; Hydrogen peroxide; Superoxide; CARBON-FIBER MICROELECTRODE; REACTIVE OXYGEN; NITRIC-OXIDE; PEROXYNITRITE; SUPEROXIDE; GRAPHENE; NANOPARTICLES; MICROSENSOR; ISCHEMIA; BIOLOGY;
D O I：
10.1016/j.coelec.2021.100809
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Electrochemical sensors are ideally suited for the detection of reactive oxygen and nitrogen species (ROS and RNS) generated during biological processes. This review discusses the latest work in the development of electrochemical microsensors for ROS/RNS and their applications for monitoring oxidative stress in biological systems. The performance of recent designs of microelectrodes and electrode materials is discussed along with their functionality in preclinical models of drug efficacy, mitochondrial distress, and endothelial dysfunction. Challenges and opportunities in translating this methodology to study the pathophysiology associated with various diseases are discussed.
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页数：10
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