TM6SF2: A Novel Genetic Player in Nonalcoholic Fatty Liver and Cardiovascular Disease

被引：80
|
作者：
Luo, Fei [1 ,2 ]
Oldoni, Federico [2 ]
Das, Avash [2 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Cardiovasc Med, 139 Renmin Middle Rd, Changsha 410011, Hunan, Peoples R China
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Genet, Dallas, TX USA
来源：
HEPATOLOGY COMMUNICATIONS | 2022年 / 6卷 / 03期
基金：
中国国家自然科学基金;
关键词：
SUPERFAMILY MEMBER 2; GENOME-WIDE ASSOCIATION; HEPATIC STEATOSIS; E167K VARIANT; MENDELIAN RANDOMIZATION; CONFERS SUSCEPTIBILITY; PNPLA3; RS738409; COMMON VARIANTS; LIPID-LEVELS; RISK;
D O I：
10.1002/hep4.1822
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Transmembrane 6 superfamily member 2 (TM6SF2) is located on chromosome 19 (19p12) and encodes for a protein of undetermined function. Genetic studies have reported the association between a nonsynonymous variant in TM6SF2 (E167K, rs58542926) with hepatic triglyceride content and its impact on the cardiovascular system. Clinical and epidemiological studies have confirmed the role of TM6SF2 in the development of nonalcoholic fatty liver disease (NAFLD). Recently, TM6SF2 was also shown to play an important role in promoting hepatic fibrosis and hepatocellular cancer in mouse models. This review aims to capture the physiological role of TM6SF2 in the regulation of lipid metabolism and its involvement in cardiometabolic diseases.
引用
收藏
页码：448 / 460
页数：13
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