Restoration of vancomycin susceptibility in Enterococcus faecalis by antiresistance determinant gene transfer

被引：19
|
作者：
Viera, CT
Tsiodras, S
Gold, HS
Coakley, EPG
Wennersten, C
Eliopoulos, GM
Moellering, RC
Inouye, RT
机构：
[1] Beth Israel Deaconess Med Ctr, Dept Med, Div Infect Dis, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 03期
关键词：
D O I：
10.1128/AAC.45.3.973-975.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We assessed the ability of gene transfer to reverse vancomycin resistance in class A (VanA) glycopeptide-resistant Enterococcus faecalis. Recombinant shuttle vectors containing a vanH promoter-vanA antisense gene cassette fully restored vancomycin susceptibility through a combined transcriptional activator binding domain decoy and inducible vanA antisense RNA effect.
引用
收藏
页码：973 / 975
页数：3
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