Photoredox Metal-Free Allylic Defluorinative Silylation of α-Trifluoromethylstyrenes with Hydrosilanes

被引：45

作者：

Luo, Cong ^{[1
]}

Zhou, Yang ^{[1
]}

Chen, Hang ^{[1
]}

Wang, Ting ^{[1
]}

Zhang, Zheng-Bing ^{[1
]}

Han, Pan ^{[1
]}

Jing, Lin-Hai ^{[1
]}

机构：

[1] China West Normal Univ, Coll Chem & Chem Engn, Chem Synth & Pollut Control Key Lab Sichuan Prov, Nanchong 637002, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 23期

基金：

中国国家自然科学基金;

关键词：

HYDROGEN-ATOM-TRANSFER; MEDICINAL CHEMISTRY; DEFLUOROSILYLATION; GENERATION; RADICALS; ALKENES; DIFLUOROALLYLATION; DERIVATIVES; DESIGN;

D O I：

10.1021/acs.orglett.2c01690

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report an efficient strategy that combines organic photoredox and hydrogen atom transfer to deliver gem-difluoroallylsilanes via defluorinative silylation of alpha-trifluoromethylstyrenes using hydrosilanes as silicon sources. This protocol provides an environmentally friendly approach for the preparation of structurally diverse gem-difluoroallylsilanes with excellent functional group compatibility and renders it suitable for late-stage modification of bioactive and complex molecules.

引用

页码：4286 / 4291

页数：6

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