New potent cytotoxic lamellarin alkaloids from Indian ascidian Didemnum obscurum

被引：107
|
作者：
Reddy, SM
Srinivasulu, M
Satyanarayana, N
Kondapi, AK
Venkateswarlu, Y [1 ]
机构：
[1] Indian Inst Chem Technol, Organ Chem Div 1, Nat Prod Lab, Hyderabad 500007, Andhra Pradesh, India
[2] Univ Hyderabad, Dept Biochem, Hyderabad 500046, Andhra Pradesh, India
来源：
TETRAHEDRON | 2005年 / 61卷 / 39期
关键词：
lamellarin alkaloids; ascidians; cytotoxic activity; coloractal cancer cells;
D O I：
10.1016/j.tet.2005.07.067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chemical investigations of the ascidian Didemnum obscurum has resulted in the isolation of four new lamellarin alkaloids, lamellarin-zeta (1), lamellarin-eta (2), lamellarin-phi (3) and lamellarin-chi, (4) along with seven known lamellarins, lamellarin-K (5), lamellarin-I (6), lamellarin-J (7), lamellarin-K triacetate (8), lamellarin-L triacetate (9), lamellarin-F (10) and lamellarin-T diacetate (11). The structures of the compounds 1-11 were established by detailed analysis of NMR spectral data. Cytotoxic activity of the isolates has been done against coloractal cancer cells. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9242 / 9247
页数：6
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