Zearalenone Exposure Triggered Cecal Physical Barrier Injury through the TGF-β1/Smads Signaling Pathway in Weaned Piglets

被引:17
|
作者
Zhang, Pengfei [1 ]
Jing, Changwei [2 ]
Liang, Ming [3 ]
Jiang, Shuzhen [1 ]
Huang, Libo [1 ]
Jiao, Ning [1 ]
Li, Yang [1 ]
Yang, Weiren [1 ]
机构
[1] Shandong Agr Univ, Dept Anim Sci & Technol, Tai An 271018, Shandong, Peoples R China
[2] Shandong Chinwhiz Co Ltd, Tech Dept, Weifang 262400, Peoples R China
[3] Shandong Baolaililai Bioengn Co Ltd, Dept Feeding Microecol, Tai An 271001, Shandong, Peoples R China
关键词
zearalenone; cecum; physical barrier; TGF-; beta; 1/Smads; piglet; GROWTH-FACTOR-BETA; INTESTINAL BARRIER; TGF-BETA; MODULATION; EXPRESSION; OVARIES; METABOLISM; MECHANISMS; MICROBIOTA; INTEGRITY;
D O I
10.3390/toxins13120902
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
This study aims to investigate the effects of exposure to different dosages of zearalenone (ZEA) on cecal physical barrier functions and its mechanisms based on the TGF-beta 1/Smads signaling pathway in weaned piglets. Thirty-two weaned piglets were allotted to four groups and fed a basal diet supplemented with ZEA at 0, 0.15, 1.5, and 3.0 mg/kg, respectively. The results showed that 1.5 and 3.0 mg/kg ZEA damaged cecum morphology and microvilli, and changed distribution and shape of M cells. Moreover, 1.5 and 3.0 mg/kg ZEA decreased numbers of goblet cells, the expressions of TFF3 and tight junction proteins, and inhibited the TGF-beta 1/Smads signaling pathway. Interestingly, the 0.15 mg/kg ZEA had no significant effect on cecal physical barrier functions but decreased the expressions of Smad3, p-Smad3 and Smad7. Our study suggests that high-dose ZEA exposure impairs cecal physical barrier functions through inhibiting the TGF-beta 1/Smads signaling pathway, but low-dose ZEA had no significant effect on cecum morphology and integrity through inhibiting the expression of smad7. These findings provide a scientific basis for helping people explore how to reduce the toxicity of ZEA in feeds.
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页数:13
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