Cytotoxic triterpenoid saponins from Aesculus glabra Willd.

被引：20
|
作者：
Yuan, Wei [1 ]
Wang, Ping [1 ]
Deng, Guangrui [1 ]
Li, Shiyou [1 ]
机构：
[1] Stephen F Austin State Univ, Natl Ctr Pharmaceut Crops, Arthur Temple Coll Forestry & Agr, Nacogdoches, TX 75972 USA
来源：
PHYTOCHEMISTRY | 2012年 / 75卷
关键词：
Aesculus glabra; Hippocastanaceae; Triterpenoid saponins; Cytotoxicity; Aesculioside; Chemotaxonomy; HYPOGLYCEMIC ACTIVITY; ASSAMICA GRIFF; HORSE CHESTNUT; SYMPLOCOS-CHINENSIS; ETHANOL ABSORPTION; BIOACTIVE SAPONINS; HIPPOCASTANUM L; WOODEN ASHES; PAVIA L; SEEDS;
D O I：
10.1016/j.phytochem.2011.11.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Twenty-four acylated polyhydroxyoleanene saponins were isolated from the seeds of Aesculus glabra. Sixteen of them, namely aesculiosides G1-G16 (1-16), were determined as compounds by spectroscopic and chemical analysis. The structural features of all 24 saponins are: (1) arabinofuranosyl units affixed to C-3 of the glucuronopyranosyl unit in the trisaccharide chain; (2) no 24-OH substitution: (3) C-2 sugar moiety substitution of the 3-O-glucuronopyranosyl unit is either glucopyranosyl or galactopyranosyl. The features of these isolated saponin structures provide more evidence for chemical taxonomy within the genus Aesculus. The cytotoxicity of the aesculiosides (1-16) were tested against A549 and PC-3 cancer cell lines with GI(50) from 5.4 to >25 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：67 / 77
页数：11
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