A turn-on and lysosome-targeted fluorescent NO releaser in water media and its application in living cells and zebrafishes

被引：7

作者：

Shen, Ronghua ^{[1
]}

Qian, Ying ^{[1
]}

机构：

[1] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2020年 / 230卷 / 230期

关键词：

Water-soluble; Turn-on fluorescent NO releaser; Lysosome-targeted; Living cells and zebraflshes imaging; NITRIC-OXIDE RELEASE; NANOPARTICLES; DERIVATIVES; DONOR; PHOTORELEASER; PROBE;

D O I：

10.1016/j.saa.2019.118024

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Due to the high activity and difficult to transport of nitric oxide, the controlled release of nitric oxide has been a new trend in the research on the biological effect of nitric oxide. In this paper, a water-soluble and turn-on fluorescent NO donor Rh-NO was synthesized. Upon 525 nm irradiation, the fluorescence of the Rh-NO at 568 nm enhanced with the quantum yield (Phi(F)) of Rh-NO changing from 5.08% to 35.96%. The mechanism of NO releasing was proved by HRMS and the Dan. The releasing time of 6 min and the releasing yield of 0.61 proved the superiority of Rh-NO. Excellent cell activity above 80% of Rh-NO and Rh guaranteed that nitric oxide was released from Rh-NO in lysosome and zebrafishes successfully, which provided a good platform to understand the biological effects of nitric oxide in lysosomes. (C) 2020 Elsevier B.V. All rights reserved.

引用

页数：7

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