Ru(II)-Catalyzed Decarbonylative Alkylation and Annulations of Benzaldehydes with Iodonium Ylides under Chelation Assistance

被引：27
|
作者：
Li, Xiang [1 ]
Shen, Yang [1 ]
Zhang, Guodong [2 ]
Zheng, Xin [1 ]
Zhao, Qing [1 ]
Song, Zihe [1 ]
机构：
[1] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Xian 710021, Shaanxi, Peoples R China
[2] Yangzhou Univ, Coll Chem & Chem Engn, 180 Siwangting Rd, Yangzhou 225002, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 29期
基金：
中国国家自然科学基金;
关键词：
C-H ACTIVATION; DIVERGENT SYNTHESIS; INDOLE ALKALOIDS; FORMAL SYNTHESIS; SALICYLALDEHYDES; CONSTRUCTION; DIBENZOFURANS; ALDEHYDES; CHROMONES; ALKYNES;
D O I：
10.1021/acs.orglett.2c01843
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Ru(II)-catalyzed decarbonylative alkylation and annulation of salicylaldehydes and 2-aminobenzaldehydes with iodonium ylides has been developed for the synthesis of dibenzo[b,d]furans and NH-free carbazolones. The reaction proceeds smoothly under mild conditions with a low catalyst loading and a broad substrate compatibility. Notably, hydroxy and free amino groups were demonstrated to be the effective directing groups, enabling the successful aldehyde C-H bond activation and subsequent decarbonylation and annulation under the inexpensive Ru(II) catalyst.
引用
收藏
页码：5281 / 5286
页数：6
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