Phase I study of mesenchymal stem cell (MSC)-derived exosomes with KRASG12D siRNA in patients with metastatic

被引:14
|
作者
Surana, Rishi
LeBleu, Valerie S.
Lee, J. Jack
Smaglo, Brandon George
Zhao, Dan
Lee, Michael Sangmin
Wolff, Robert A.
Overman, Michael J.
Mendt, Mayela C.
McAndrews, Kathleen M.
Yang, Sujuan
Rezvani, Katy
Kalluri, Raghu
Maitra, Anirban
Shpall, Elizabeth J.
Pant, Shubham
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Canc Med, Houston, TX 77030 USA
[2] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA
[5] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[6] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA
[7] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
[8] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
[9] Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1200/JCO.2022.40.4_suppl.TPS633
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
TPS633
引用
收藏
页数:3
相关论文
共 50 条
  • [1] iExplore: A phase I study of mesenchymal stem cell derived exosomes with KrasG12D siRNA for metastatic pancreas cancer patients harboring the KrasG12D mutation
    Smaglo, Brandon G.
    LeBleu, Valerie S.
    Lee, J. Jack
    Maitra, Anirban
    Kalluri, Raghu
    Rezvani, Katy
    Soto, Luisa M. Solis
    Hurd, Mark
    Kaur, Indreshpal
    Vilchez, Mayela C. Mendt
    Kirtley, Michelle L.
    Shaftoe, Stacy L.
    Morelli, Maria Pia
    Overman, Michael J.
    Zhou, Dan
    Wolff, Robert A.
    Tu, Janet
    Willis, Jason A.
    Huey, Ryan W.
    Lee, Michael S.
    Bhosale, Priya R.
    Dworsky, Suzanne W.
    Xu, Li
    Pant, Shubham
    Shpall, Elizabeth J.
    CANCER RESEARCH, 2024, 84 (02)
  • [2] Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials
    Ahmed Lotfy
    Noha M. AboQuella
    Hongjun Wang
    Stem Cell Research & Therapy, 14
  • [3] Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials
    Lotfy, Ahmed
    AboQuella, Noha M.
    Wang, Hongjun
    STEM CELL RESEARCH & THERAPY, 2023, 14 (01)
  • [4] Wound Healing Effects of Human Mesenchymal Stem Cell (MSC)-derived Exosomes
    An, Seungwon
    Anwar, Khandaker
    Lee, Hyungjo
    Ghassemi, Mahmood
    Djalilian, Ali
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2023, 64 (08)
  • [5] Therapeutic Features and Updated Clinical Trials of Mesenchymal Stem Cell (MSC)-Derived Exosomes
    Lee, Byung-Chul
    Kang, Insung
    Yu, Kyung-Rok
    JOURNAL OF CLINICAL MEDICINE, 2021, 10 (04) : 1 - 18
  • [6] Snail Cooperates with KrasG12D In Vivo to Increase Stem Cell Factor and Enhance Mast Cell Infiltration
    Knab, Lawrence M.
    Ebine, Kazumi
    Chow, Christina R.
    Raza, Sania S.
    Sahai, Vaibhav
    Patel, Akash P.
    Kumar, Krishan
    Bentrem, David J.
    Grippo, Paul J.
    Munshi, Hidayatullah G.
    MOLECULAR CANCER RESEARCH, 2014, 12 (10) : 1440 - 1448
  • [7] Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy
    Behnoush Sohrabi
    Behnaz Dayeri
    Elahe Zahedi
    Shahrouz Khoshbakht
    Najme Nezamabadi Pour
    Hamta Ranjbar
    Abolfazl Davari Nejad
    Mahdi Noureddini
    Behrang Alani
    Cancer Gene Therapy, 2022, 29 : 1105 - 1116
  • [8] Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy
    Sohrabi, Behnoush
    Dayeri, Behnaz
    Zahedi, Elahe
    Khoshbakht, Shahrouz
    Pour, Najme Nezamabadi
    Ranjbar, Hamta
    Nejad, Abolfazl Davari
    Noureddini, Mahdi
    Alani, Behrang
    CANCER GENE THERAPY, 2022, 29 (8-9) : 1105 - 1116
  • [9] Interaction of mesenchymal stem cell (MSC)-derived exosomes with microglia isolated after acute neonatal stroke
    Pathipati, P.
    LeCuyer, M.
    Faustino, J.
    Strivelli, J.
    Phinney, D. G.
    Vexler, Z.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2019, 39 : 634 - 634
  • [10] EGCG inhibits pancreatic cancer growth and stem cell characteristics in xenografts and KrasG12D transgenic mice models
    Tang, Su-Ni
    Marsh, Luke
    Shankar, Sharmila
    Srivastava, Rakesh K.
    CANCER RESEARCH, 2011, 71