Development and validation of stability indicating assay method of cetirizine hydrochloride by HPLC

被引:0
|
作者
Khan, Muhammad Imran [2 ]
Murtaza, Ghulam [1 ]
Awan, Sher [3 ]
Iqbal, Muhammad [2 ]
Waqas, Muhammad Khurram [2 ]
Rasool, Akhtar [4 ]
Fatima, Urooj [2 ]
Bin Asad, Muhammad Hassham Hassan [1 ]
Kahlid, Anwar [5 ]
Usman, Faisal [6 ]
Najam-us-Saqib, Qazi [1 ]
Khan, Shujaat Ali [4 ]
Farzana, Kalsoom [6 ]
Mahmood, Seema [7 ]
Hussain, Izhar [1 ]
机构
[1] COMSATS Inst Informat Technol, Dept Pharmaceut Sci, Abbottabad, Pakistan
[2] Univ Faisalabad, Dept Pharm, Faisalabad, Pakistan
[3] Univ Sargodha, Dept Pharm, Sargodha, Pakistan
[4] Islamia Univ Bahawalpur, Dept Pharm, Bahawalpur, Pakistan
[5] COMSATS Inst Informat Technol, Dept Chem, Abbottabad, Pakistan
[6] Bahauddin Zakariya Univ, Fac Pharm, Multan, Pakistan
[7] Bahauddin Zakariya Univ, Inst Pure & Appl Biol, Multan, Pakistan
来源
AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY | 2011年 / 5卷 / 02期
关键词
High performance liquid chromatography; cetirizine hydrochloride; pharmaceutical preparations;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A new simple and rapid high performance liquid chromatography (HPLC) method was developed for the determination of cetirizine hydrochloride (CTZ) in tablets using CLC-ODS reverse phase column (4.6 x 250 mm, 5 mu m). Salicylic acid was used as internal standard. A mixture of methanol and water of 70: 30 with pH 4 (adjusted with o-phosphoric acid) was used as mobile phase. The eluents were detected at 231 nm. The coefficient of determination of calibration curve for CTZ and salicylic acid in mobile phase were 0.9898 and 0.9925, respectively. The limit of detection for CTZ was 4 mu g ml(-1). The proposed method was successfully applied for the stability study of CTZ. The CTZ was found to be stable at accelerated condition of temperature and relative humidity after storage of six months. This method can be used for the routine quality control and dosage form assay of CTZ in pharmaceutical preparations.
引用
收藏
页码:143 / 149
页数:7
相关论文
共 50 条
  • [21] DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC ASSAY METHOD FOR DETERMINATION OF PHENOBARBITONE IN BULK DRUG AND TABLET FORMULATION
    Mhatre, P. R.
    Gatkal, S. H.
    Chopade, V. V.
    Choudhari, P. D.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2013, 4 (05): : 1820 - 1826
  • [22] Development and Validation of Stability indicating HPLC method for determination of related substances and assay of Monobenzone drug substance
    Mangukiya, Manoj A.
    Bagwe, Pritam V.
    Desai, Aman A.
    Joshi, Shreerang V.
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2023, 100 (09)
  • [23] DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING RP-HPLC ASSAY METHOD FOR ENTACAPONE IN ENTACAPONE TABLETS
    Dhawan, Raj Kumar
    Ravi, S.
    Subburaju, T.
    Revathi, H.
    Arul, C.
    Rao, N. Ganapathi
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2013, 4 (03): : 1227 - 1232
  • [24] Carbamazepine: Stability indicating HPLC assay method
    Rajadhyaksha, Namita S.
    Jain, Satish P.
    Amin, Purnima D.
    ANALYTICAL LETTERS, 2007, 40 (13) : 2506 - 2514
  • [25] Development and Validation of a Stability-Indicating HPLC Method for the Assay of Carvedilol in Pure and Tablet Dosage Forms
    Ahmed, Sofia
    Khan, Anam
    Sheraz, Muhammad Ali
    Bano, Rehana
    Ahmad, Iqbal
    CURRENT PHARMACEUTICAL ANALYSIS, 2018, 14 (02) : 139 - 152
  • [26] STABILITY INDICATING ASSAY METHOD DEVELOPMENT AND VALIDATION OF PREGABALIN IN PHARMACEUTICAL DOSAGE FORMS BY RP-HPLC
    Sneha, P.
    Srinivas, Prathima
    INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 2 (06): : 1038 - 1047
  • [27] Development and validation of a novel RP-HPLC method for stability-indicating assay of Abiraterone acetate
    Reddy, B. Jala Chandra
    Sarada, N. C.
    JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2016, 39 (07) : 354 - 363
  • [28] DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF SALMETEROL XINAFOATE
    Damle, Mrinalini
    Choudhari, Suresh
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2019, 10 (04): : 1865 - 1869
  • [29] Development and validation of stability indicating HPLC method for determination of adrenaline tartrate
    Kongkiatpaiboon, Sumet
    Dunagdee, Nongnaphat
    Chewchinda, Savita
    Poachanukoon, Orapan
    Amnuaypattanapon, Kumpol
    JOURNAL OF KING SAUD UNIVERSITY SCIENCE, 2019, 31 (01) : 48 - 51
  • [30] Development and validation of stability indicating RP-HPLC method for voriconazole
    Khetre, A. B.
    Sinha, P. K.
    Damle, Mrinalini C.
    Mehendre, R.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 71 (05) : 509 - 514