Synthesis of 1,2,3,4-Tetrahydroisoquinoline Derivatives

被引：0

作者：

Feng, Zhiqiang ^{[1
]}

Yang, Xiaoli ^{[1
]}

Ye, Yuanfeng ^{[1
]}

Hao, Lingyun ^{[1
]}

Hu, Jingang ^{[2
]}

机构：

[1] Jinling Inst Technol, Sch Mat Engn, Nanjing 211169, Peoples R China

[2] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 31卷 / 07期

关键词：

2-(3-methoxyphenyl)ethylamine; 1,2,3,4-tetrahydroisoquinoline; cyclization; INHIBITORS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of important 1,2,3,4-tetrahydroisoquinoline derivatives were synthesized from 2-(3-methoxyphenyl)ethylamine and ethyl chloroformate by nucleophilic substitution, cyclization, LiA1H(4) reduction and other reactions amounting to 9 steps. The structures of the products were characterized by IR, H-1 NMR spectra and elemental analysis. Compared to the traditional synthetic procedures of tetrahydroisoquinoline, our procedures were temperate, convenient, economical, high-yielding and environment-friendly.

引用

页码：1087 / 1090

页数：4

共 24 条

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