Neuropsychological profiles and short-term outcome in late-onset depression

被引:0
|
作者
Chui, William W. H. [1 ]
Cheung, Eric F. C. [1 ]
Lam, Linda C. W. [2 ]
机构
[1] Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
关键词
neuropsychology; neurological soft signs; late-onset depression; short-term prognosis; DEMENTIA RATING-SCALE; LATE-LIFE; EXECUTIVE DYSFUNCTION; TREATMENT RESPONSE; WHITE-MATTER; CHINESE VERSION; IMPAIRMENT; SIGNS; VALIDATION; COMMUNITY;
D O I
10.1002/gps.2548
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: Neuropsychological impairments are common in older persons with late-onset depression. This study examined the relationship between neuropsychological profiles and short-term outcome in late-onset depression. Methods: A total of 54 non-demented Chinese elders presented with their first major depressive episode after 60 years of age participated in this study and were treated according to a standardised protocol. At entry, they were assessed on neurological signs (Parkinsonian features and neurological soft signs) and neuropsychological measures (executive function, psychomotor-speed, attention and working memory, episodic memory, conceptualisation, construction and global cognitive function). The Hamilton Depression Rating Scale (HAM-D) was administered at baseline, the sixth and 12th week of treatment. Results: Abnormal fist-edge-palm (FEP) test, a sign reflecting impairment in motor sequencing, was more common in non-remitters (defined as HAM-D score above 7) at the 12th week of treatment. Conclusions: The FEP test may be included in the clinical assessment for patients with late-onset depression to identify a susceptible group who may require more intensive treatment. Further research is warranted to ascertain the link between late-onset depression, neuropsychological deficits and prognosis. Copyright (c) 2010 John Wiley & Sons, Ltd.
引用
收藏
页码:458 / 465
页数:8
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