Predicting drug hypersensitivity by in vitro tests

被引：0
|
作者：
Pichler, Werner J. [1 ]
机构：
[1] Univ Bern, Inselspital, Dept Rheumatol & Clin Immunol Allergol, CH-3010 Bern, Switzerland
来源：
ALTEX-ALTERNATIVEN ZU TIEREXPERIMENTEN | 2007年 / 24卷
关键词：
T cell; allergy; hypersensitivity; TCR;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Recently it was found that drugs causing drug hypersensitivities do not only rely on the formation of hapten-carrier conjugates but can stimulate T cells directly via their T cell receptors for antigen. This new mechanism was termed pharmacological interaction of drugs with immune receptors (p-i concept). It is frequent in systemic drug hypersensitivity reactions and has major implications for predicting them. First experiments to identify such drugs able to interact with T cells are presented.
引用
收藏
页码：49 / 52
页数：4
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