A highly efficient kinetic resolution of Morita-Baylis-Hillman adducts achieved by N-Ar axially chiral Pd-complexes catalyzed asymmetric allylation

被引：40
|
作者：
Wang, Feijun [1 ,2 ]
Li, Shengke [1 ,2 ]
Qu, Mingliang [1 ,2 ]
Zhao, Mei-Xin [1 ,2 ]
Liu, Lian-Jun [1 ,2 ]
Shi, Min [1 ,2 ,3 ]
机构：
[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
[2] E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 48期
基金：
中国国家自然科学基金;
关键词：
PRIMARY ALLYLIC AMINES; CONJUGATE ADDITION; HETEROCYCLIC CARBENE; PALLADIUM COMPLEXES; ALCOHOLS; ACIDS; LIGAND; 1,4-ADDITION; SUBSTITUTION; ALKYLATIONS;
D O I：
10.1039/c1cc15543a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Palladium complexes with an axially chiral N-Ar framework have been developed. These complexes showed high stereoselectivities in asymmetric allylic arylation to achieve the kinetic resolution of Morita-Baylis-Hillman adducts, affording up to 99% ee of (E)-allylation products and 92% ee of recovered Morita-Baylis-Hillman adducts.
引用
收藏
页码：12813 / 12815
页数：3
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