Modeling cancer processes with CRISPR-Cas9

被引：9

作者：

Lu, Xiao-Jie ^{[1
]}

Qi, Xiaolong ^{[2
,3
]}

Zheng, Dong-Hui ^{[4
]}

Ji, Li-Juan ^{[5
]}

机构：

[1] Tongji Univ, Shanghai East Hosp, Sch Med, Dept Gastroenterol, Shanghai 200092, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Ctr Canc, Biotherapy Ctr, Zhengzhou 450052, Peoples R China

[3] Tongji Univ, Tongji Hosp, Sch Med, Dept Gastroenterol & Hepatol, Shanghai 200092, Peoples R China

[4] Second Peoples Hosp Huaian, Dept Nephrol, Huaian, Peoples R China

[5] Second Peoples Hosp Huaian, Dept Rehabil, Huaian, Peoples R China

来源：

TRENDS IN BIOTECHNOLOGY | 2015年 / 33卷 / 06期

关键词：

GENOME; GENERATION; NUCLEASES; EVENTS;

D O I：

10.1016/j.tibtech.2015.03.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

CRISPR-Cas9 is an RNA-guided site-specific DNA editing tool which, together with its reprogrammed versions such as nickase Cas9 and dead Cas9, enables quick modeling of desired combinations of cancer-associated genomic and/or epigenetic aberrations simultaneously or sequentially, thus facilitating massive functional interrogations and therapy testing.

引用

页码：317 / 319

页数：3

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