Developing miRNA therapeutics for cardiac repair in ischemic heart disease

被引：30
|
作者：
Zhu, Kai [1 ,2 ]
Liu, Dingqian [1 ,2 ]
Lai, Hao [1 ,2 ]
Li, Jun [1 ,2 ]
Wang, Chunsheng [1 ,2 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, Dept Cardiac Surg, Shanghai 200032, Peoples R China
[2] Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China
来源：
JOURNAL OF THORACIC DISEASE | 2016年 / 8卷 / 09期
基金：
美国国家科学基金会;
关键词：
MicroRNAs (miRNAs); modulation; stem cells; regeneration; cardiac repair; PROGENITOR-CELL SENESCENCE; CORONARY-ARTERY-DISEASE; STEM-CELLS; IN-VIVO; DOWN-REGULATION; MIR-34; FAMILY; MICRORNA-34A; ANGIOGENESIS; DIFFERENTIATION; FIBROBLASTS;
D O I：
10.21037/jtd.2016.08.93
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
MicroRNAs (miRNAs) families have been found to be powerful regulators in a wide variety of diseases, which enables the possible use of miRNAs in therapeutic strategies for cardiac repair after ischemic heart disease. This review provides some general insights into miRNAs modulation for development of current molecular and cellular therapeutics in cardiac repair, including endogenous regeneration, endogenous repair, stem cells transplantation, and reprogramming. We also review the delivery strategies for miRNAs modulation, and briefly summarize the current bench and clinical efforts that are being made to explore miRNAs as the future therapeutic target.
引用
收藏
页码：E918 / E927
页数：10
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