Predisposition locus for major depression at chromosome 12q22-12q23.2

被引:132
作者
Abkevich, V
Camp, NJ
Hensel, CH
Neff, CD
Russell, DL
Hughes, DC
Plenk, AM
Lowry, MR
Richards, RL
Carter, C
Frech, GC
Stone, S
Rowe, K
Chau, CA
Cortado, K
Hunt, A
Luce, K
O'Neil, G
Poarch, J
Potter, J
Poulsen, GH
Saxton, H
Bernat-Sestak, M
Thompson, V
Gutin, A
Skolnick, MH
Shattuck, D
Cannon-Albright, L
机构
[1] Myriad Genet, Salt Lake City, UT 84108 USA
[2] Intermt Hlth Care, Salt Lake City, UT USA
[3] Childrens Ctr, Salt Lake City, UT USA
[4] Valley Mental Hlth, Salt Lake City, UT USA
关键词
D O I
10.1086/379978
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Major depression disorder is a common psychiatric disease with a major economic impact on society. In many cases, no effective treatment is available. The etiology of major depression is complex, but it is clear that the disease is, to a large extent, determined genetically, especially among individuals with a familial history of major depression, presumably through the involvement of multiple predisposition genes in addition to an environmental component. As a first step toward identification of chromosomal loci contributing to genetic predisposition to major depression, we have conducted a genomewide scan by using 628 microsatellite markers on 1,890 individuals from 110 Utah pedigrees with a strong family history of major depression. We identified significant linkage to major depression in males at marker D12S1300 (multipoint heterogeneity LOD score 4.6; P = .00003 after adjustment for multiple testing). With additional markers, the linkage evidence became highly significant, with the multipoint heterogeneity LOD score at marker D12S1706 increasing to 6.1 (P = .0000007 after adjustment for multiple testing). This study confirms the presence of one or more genes involved in psychiatric diseases on the q arm of chromosome 12 and provides strong evidence for the existence of a sex-specific predisposition gene to major depression at 12q22-q23.2.
引用
收藏
页码:1271 / 1281
页数:11
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