Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures

被引：80
|
作者：
Moyer, Tyson J. [1 ,2 ]
Kassam, Hussein A. [1 ,3 ]
Bahnson, Edward S. M. [1 ,3 ]
Morgan, Courtney E. [1 ,3 ]
Tantakitti, Faifan [1 ,2 ]
Chew, Teng L. [1 ,4 ]
Kibbe, Melina R. [1 ,3 ]
Stupp, Samuel I. [1 ,2 ,4 ,5 ]
机构：
[1] Northwestern Univ, Simpson Querrey Inst BioNanotechnol, Chicago, IL 60611 USA
[2] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA
[3] Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL 60611 USA
[4] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
[5] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
来源：
SMALL | 2015年 / 11卷 / 23期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
NEOINTIMAL HYPERPLASIA; ANTITUMOR-ACTIVITY; NITRIC-OXIDE; NANOPARTICLES; ANGIOPLASTY; DELIVERY; RESTENOSIS; PREVENTION; CANCER; FLOW;
D O I：
10.1002/smll.201403429
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2750 / 2755
页数：6
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