Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania

被引:8
|
作者
Turaiche, Mirela [1 ]
Feciche, Bogdan [2 ]
Gluhovschi, Adrian [1 ,3 ]
Bratosin, Felix [1 ]
Bogdan, Iulia [1 ]
Bota, Adrian Vasile [1 ]
Grigoras, Mirela Loredana [1 ,4 ]
Gurban, Camelia Vidita [1 ,5 ]
Cerbu, Bianca [1 ]
Toma, Ana-Olivia [6 ]
Gurumurthy, Srivathsava [7 ]
Wulandari, Prima Hapsari [8 ]
Marincu, Iosif [1 ]
机构
[1] Victor Babes Univ Med & Pharm, Methodol & Infect Dis Res Ctr, Dept Infect Dis, Timisoara 300041, Romania
[2] Satu Mare Cty Emergency Hosp, Dept Urol, Str Ravensburg 2, Satu Mare 440192, Romania
[3] Victor Babes Univ Med & Pharm Timisoara, Dept Obstet & Gynecol, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[4] Victor Babes Univ Med & Pharm Timisoara, Dept Anat & Embryol, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[5] Victor Babes Univ Med & Pharm, Dept Biochem, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[6] Victor Babes Univ Med & Pharm, Dept Microbiol, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[7] Rajiv Gandhi Univ Hlth Sci, Mysore Med Coll & Res Inst, Irwin Rd, Mysuru 570001, India
[8] Harvard Med Sch, Massachusetts Gen Hosp, 55 Fruit St, Boston, MA 02114 USA
来源
PATHOGENS | 2022年 / 11卷 / 09期
关键词
measles; infectious disease; public health; DISEASE;
D O I
10.3390/pathogens11091018
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Measles is a highly infectious and sometimes deadly illness that is preventable with vaccination. The present research aims to analyze the most recent measles epidemic from Romania that occurred in a population with a falling desire to receive immunizations, by detailing the clinical picture and biological profile of hospitalized patients. A secondary goal of the present research is to identify characteristics that increase the likelihood of a longer hospitalization and the development of measles-related pneumonia. A retrospective cohort study was conducted to follow the course and effects of measles virus infection in adult hospitalized patients who were divided into two groups based on whether they had been in the hospital for more than 6 days or fewer than 6 days. A total of 114 adult patients with measles were eligible to participate in the trial if they had a positive measles-specific IgM antibody test resulting from the study. The average age in the short hospital stay group was 28.1 years, while the average age in the long hospital stay group was 31.9 years. There was a statistically significant difference in the number of Roma persons in the research groups, with 17.4 percent of them having a lengthy hospital stay compared to 5.9 percent in the group with a short hospital stay, according to the findings. It was observed that many patients had a long hospitalization associated with chronic lung disease (OR = 1.07), liver damage (OR = 1.66), Roma ethnicity (OR = 1.79), a long duration elapsed from the last MMR dose (OR = 2.02), elevated c-reactive protein (OR = 2.17), the presence of bilateral pulmonary condensations on X-ray (OR = 3.13), and elevated procalcitonin (OR = 3.49). The same significant independent risk factors were also associated with the development of pneumonia. It is of imperative need to address these risk factors in a patient with measles, moreover in association with an unknown status of vaccination. Vaccination awareness against measles must be pushed in Romania to determine a higher than 95% coverage. Significant efforts are still needed to ensure improved protection against measles epidemics within a specific region or population and, more importantly, in patients with significant risk factors for complications, as described in this study.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] Factors associated with prolonged hospitalization, readmission, and death in elderly heart failure patients in western Romania
    Gyalai-Korpos, Istvan
    Ancusa, Oana
    Dragomir, Tiberiu
    Tomescu, Mirela Cleopatra
    Marincu, Iosif
    CLINICAL INTERVENTIONS IN AGING, 2015, 10 : 561 - 568
  • [2] Association between Clinical Features and Prolonged Hospitalization of Heart Failure Patients
    Suzuki, Chihiro
    Shyouin, Kyouko
    Kato, Tamon
    Aizawa, Katsuyuki
    Kamiyosi, Yuichi
    Aso, Shinichi
    Aoki, Shizue
    Ikeda, Uichi
    JOURNAL OF CARDIAC FAILURE, 2015, 21 (10) : S161 - S161
  • [3] Measles-Clinical and Biological Manifestations in Adult Patients, Including a Focus on the Hepatic Involvement: Results from a Single-Center Observational Cohort Study from Romania
    Birlutiu, Victoria
    Birlutiu, Rares-Mircea
    JOURNAL OF CLINICAL MEDICINE, 2024, 13 (18)
  • [4] CLINICAL FEATURES OF TUNISIAN PATIENTS WITH BEHCET'S DISEASE: A RETROSPECTIVE MONOCENTRIC STUDY
    Bellakhal, S.
    Ajili, F.
    Boussetta, N.
    Metoui, L.
    Sayhi, S.
    Laabidi, J.
    Louzir, B.
    Ben Abdelhafidh, N.
    Othmani, S.
    ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 : 936 - 936
  • [5] Predictors of prolonged hospital length of stay and mortality in adult patients with diabetic ketoacidosis in Lebanon: a monocentric retrospective study
    Raffoul, Peter
    Ishak, Georges
    Hazimeh, Abbass
    Hazimeh, Yusef
    JOURNAL OF DIABETES AND METABOLIC DISORDERS, 2025, 24 (01)
  • [6] THE ENIGMATIC PROFILE: UNRAVELING CLINICAL AND BIOLOGICAL FEATURES IN COVID-19 PATIENTS
    Esanu, Irina Mihaela
    Gavril, Oana Irina
    Zota, Madalina Ioana
    Drugescu, A.
    Ancuta, Codrina
    Grosu-Creanga, Ionela
    Gavril, R. S.
    MEDICAL-SURGICAL JOURNAL-REVISTA MEDICO-CHIRURGICALA, 2023, 127 (04): : 516 - 524
  • [7] MONOCENTRIC REAL LIFE COHORT OF UNSELECTED CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS (CLL): ANALYSIS OF BIOLOGICAL AND CLINICAL FEATURES
    Murru, R.
    Loghi, M. G.
    Uda, S.
    Tandurella, I. M. C.
    Culurgioni, F.
    Pulisci, D.
    Musiu, C.
    Cabras, M. G.
    HAEMATOLOGICA, 2017, 102 : 121 - 121
  • [8] Clinical features of pediatric-versus adult-onset hidradenitis suppurativa: results of a monocentric retrospective study
    Di Cesare, Antonella
    Rosi, Elia
    Fastame, Maria Thais
    Senatore, Stefano
    Ricceri, Federica
    Prignano, Francesca
    EXPERIMENTAL DERMATOLOGY, 2021, 30 : 38 - 39
  • [9] Measles outbreak in the adult age group: Clinical, laboratory, and epidemiological features of the 11 patients admitted to the hospital
    Gungor, Kultural
    Bukavaz, Sebnem
    Ekuklu, Galip
    JOURNAL OF MEDICAL VIROLOGY, 2024, 96 (04)
  • [10] Cystic echinococcosis in adult hospitalized patients: A 10-year retrospective study in Western Romania
    Lupu, M. A.
    Dragomir, A.
    Paduraru, A. A.
    Ritiu, S. A.
    Lazar, F.
    Olariu, S.
    Valceanu, D.
    Botoca, M. R.
    Burlacu, O. N.
    Cretu, O. M.
    Olariu, T. R.
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2018, 73 : 299 - 300