Therapeutic Drug Monitoring-Guided Crushed Sofosbuvir-Velpatasvir Treatment: A Case Study

被引：4
|
作者：
Lalanne, Sebastien [1 ,2 ]
Jezequel, Caroline [3 ]
Tron, Camille [1 ,2 ]
Verdier, Marie-Clemente [1 ,2 ]
Mercerolle, Marion [4 ]
Pronier, Charlotte [5 ]
Guyader, Dominique [2 ,3 ]
Lemaitre, Florian [1 ,2 ]
机构：
[1] Rennes Univ Hosp, Fac Med, Dept Biol & Clin Pharmacol, Rennes, France
[2] Inserm, CIC P Clin Invest Ctr 1414, Rennes, France
[3] Rennes Univ Hosp, Liver Dis Unit, Rennes, France
[4] Rennes Univ Hosp, Dept Pharm, Rennes, France
[5] Rennes Univ Hosp, Dept Virol, Rennes, France
来源：
THERAPEUTIC DRUG MONITORING | 2020年 / 42卷 / 02期
关键词：
sofosbuvir; velpatasvir; crushing; pharmacokinetics; exposure;
D O I：
10.1097/FTD.0000000000000718
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
In this study, the authors report the case of a patient diagnosed with hepatitis C virus who was treated with sofosbuvir-velpatasvir (400/100 mg). As the patient was unable to swallow whole tablets, therapeutic drug monitoring was performed to evaluate the effect of crushing sofosbuvir-velpatasvir tablets on drug absorption and global exposure.
引用
收藏
页码：163 / 164
页数：2
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