Silyl-functionalised silver rhodium and iridium N-heterocyclic carbene complexes with promising cytotoxicity and antimicrobial potential

被引：4
|
作者：
Karatas, Mert Olgun [1 ]
Keskin, Tuba [2 ]
Ozdemir, Namik [3 ]
Kucukbay, Hasan [1 ]
Tekin, Suat [2 ]
Mansur, Ahmet [4 ]
Gunal, Selami [5 ]
Sandal, Suleyman [2 ]
机构：
[1] Inonu Univ, Fac Sci, Dept Chem, TR-9044280 Malatya, Turkey
[2] Inonu Univ, Fac Med, Dept Physiol, TR-9044280 Malatya, Turkey
[3] Ondokuz Mayis Univ, Fac Educ, Dept Math & Sci Educ, TR-9055139 Samsun, Turkey
[4] Malatya Turgut Ozal Univ, Fac Med, Dept Microbiol, TR-9044280 Malatya, Turkey
[5] Inonu Univ, Fac Pharm, Dept Microbiol, TR-9044280 Malatya, Turkey
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2022年 / 146卷
关键词：
N -heterocyclic carbene; Silver; Rhodium; Iridium; Cytotoxicity; Antimicrobial; METAL-COMPLEXES; CANCER-CELLS; LIGANDS; NHC; BENZIMIDAZOLE; CATALYSTS; GOLD(I); BEARING; SALTS;
D O I：
10.1016/j.inoche.2022.110080
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In the present study, we have synthesized Ag, Rh, and Ir complexes of a silyl-substituted NHC ligand in order to investigate their biological properties. Firstly, Ag-NHC (2) complex was synthesized by the interaction of Ag2O with benzimidazolium iodide (1). Rh-(3) and Ir-NHC (4) complexes were synthesized by the transmetalation reaction between Ag-NHC and [M(cod)Cl]2 (M = Rh or Ir) dimers. The complexes were characterised by NMR spectroscopy and elemental analyses, and crystal structures of Rh-and Ir-NHC (3 and 4) were also reported. The cytotoxic effects of the complexes were tested on four human cancer cell lines and the antimicrobial activities of the complexes were tested against a panel of nine pathogenic microorganisms. The complexes performed com-parable or better activity than standards, cisplatin and AgNO3.
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页数：8
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