Targeting the epigenome for treatment of cancer

被引：45
|
作者：
Geutjes, E-J
Bajpe, P. K.
Bernards, R. [1 ,2 ]
机构：
[1] Netherlands Canc Inst, Div Mol Carcinogenesis, Ctr Biomed Genet, NL-1066 CX Amsterdam, Netherlands
[2] Netherlands Canc Inst, Canc Genom Ctr, NL-1066 CX Amsterdam, Netherlands
来源：
ONCOGENE | 2012年 / 31卷 / 34期
关键词：
cancer epigenetics; epigenetic therapy; DNA methylation; histone modifications; nucleosome remodelling; HISTONE-DEACETYLASE INHIBITOR; TUMOR-SUPPRESSOR GENE; PHASE-II TRIAL; POLYCOMB-GROUP PROTEIN; CHROMATIN-REMODELING FACTOR; SUBEROYLANILIDE HYDROXAMIC ACID; DEMETHYLASE JMJD3 CONTRIBUTES; TRANSITIONAL-CELL CARCINOMA; CONVENTIONAL CARE REGIMENS; MESSENGER-RNA EXPRESSION;
D O I：
10.1038/onc.2011.552
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer genome analyses have revealed that the enzymes involved in epigenetic gene regulation are frequently deregulated in cancer. Here we describe the enzymes that control the epigenetic state of the cell, how they are affected in cancer and how this knowledge can be exploited to treat cancer with a new arsenal of selective therapies. Oncogene (2012) 31, 3827-3844; doi: 10.1038/onc.2011.552; published online 5 December 2011
引用
收藏
页码：3827 / 3844
页数：18
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