Changes in motor cortical excitability in humans following orally administered theophylline

被引：11
|
作者：
Nardone, R [1 ]
Buffone, E [1 ]
Covi, M [1 ]
Lochner, PG [1 ]
Tezzon, F [1 ]
机构：
[1] F Tappeiner Hosp, Dept Neurol, I-39012 Merano, BZ, Italy
来源：
NEUROSCIENCE LETTERS | 2004年 / 355卷 / 1-2期
关键词：
theophylline; transcranial magnetic stimulation; gamma-aminobutyric acid;
D O I：
10.1016/j.neulet.2003.10.055
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of theophylline on human corticospinal excitability were studied using transcranial magnetic stimulation (TMS) before and after double-blind oral administration of theophylline or placebo in 20 healthy volunteers. TMS measurements included resting and active motor threshold, silent period, intracortical inhibition (ICI), and intracortical facilitation. F-wave and compound muscle action potential (CMAP) were also measured. Theophylline produces a reduction in ICI, while other parameters of corticospinal excitability remained unaffected. Since ICI is thought to depend on GABA(A) intracortical inhibitory mechanisms, our data suggest that the increase of human motor cortex excitability is the result of a decrease in GABAergic transmission. Our results further support the hypothesis that theophylline might induce convulsions by inhibiting GABA(A) receptor binding. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：65 / 68
页数：4
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