Synthesis, anti-microbial activity and molecular docking studies on triazolylcoumarin derivatives

被引：6

作者：

Satheeshkumar, Chinnadurai ^{[1
,2
]}

Ravivarma, Mahalingam ^{[1
]}

Arjun, Pandian ^{[3
]}

Silambarasan, Vaithiyanathan ^{[4
]}

Raaman, Nanjian ^{[3
]}

Velmurugan, Devadasan ^{[4
]}

Song, Changsik ^{[2
]}

Rajakumar, Perumal ^{[1
]}

机构：

[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India

[2] Sungkyunkwan Univ, Dept Chem, Suwon 440746, Gyeonggi, South Korea

[3] Univ Madras, Nat Prod & Plant Tissue Culture Lab, Ctr Adv Studies Bot, Fungal Biotechnol, Madras 600025, Tamil Nadu, India

[4] Univ Madras, Ctr Adv Study Crystallog & Biophys, Madras 600025, Tamil Nadu, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2015年 / 127卷 / 03期

关键词：

Coumarin; 1,2,3-triazole; anti-microbial; molecular docking and ADMET; COUMARIN; ROUTE;

D O I：

10.1007/s12039-015-0810-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of triazolylcoumarins was synthesized by the cycloaddition of acetylenic derivatives to azide in the presence of Cu(I) catalyst at room temperature. All the synthesized compounds were evaluated for their anti-microbial activity against Gram-positive (B. subtilis and S. aureus), Gram-negative bacteria (K. pneumonia and P. vulgaris) and human pathogenic fungi (C. tropicalis and C. krusei), with tetracycline and fluconazole as standards for anti-microbial and anti-fungal activity. Triazolylcoumarins exhibit anti-microbial activity against all the tested pathogens, which is further supported by molecular docking studies.

引用

页码：565 / 574

页数：10

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