THIAZIDE AND THIAZIDE-LIKE DIURETICS: HOW TO MAKE THE RIGHTT CHOICE?

被引:0
|
作者
Ostroumova, O. D. [1 ]
Polyakova, O. A. [1 ]
Listratova, A., I [1 ]
Logunova, N. A. [2 ]
Gorohova, T., V [2 ]
机构
[1] Russian Med Acad Continuous Profess Educ, Moscow, Russia
[2] Servier JSC, Moscow, Russia
关键词
Combination antihypertensive therapy; indapamide; chlortalidone; hydrochlorothiazide; LEFT-VENTRICULAR HYPERTROPHY; ISOLATED SYSTOLIC HYPERTENSION; BLOOD-PRESSURE; ANTIHYPERTENSIVE DRUGS; INDAPAMIDE SR; COGNITIVE FUNCTION; INCIDENT DEMENTIA; SERUM POTASSIUM; DOUBLE-BLIND; LONG-TERM;
D O I
10.18087/cardio.2022.1.n1862
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Most patients with arterial hypertension (AH) require a combination treatment to achieve the goal blood pressure. According to Russian and international clinical guidelines on the treatment of AH patients, various antihypertensive drugs may be combined; however, not all combinations have similar profiles of safety and clinical efficacy. In this respect, special attention is given to combinations of renin-angiotensin-aldosterone system inhibitors and thiazide (hydrochlorothiazide) or thiazide-like (chlortalidone, indapamide) diuretics. Diuretics also differ in their mechanisms of action, presence of pleiotropic effects and organ-protective properties, effects on the prognosis, and in the evidence base. This review discusses the place of thiazide and thiazide-like diuretics in the treatment of patients with AH and provides an evaluation of major differences in pharmacological and clinical effects of drugs of the diuretic class.
引用
收藏
页码:89 / 97
页数:9
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