Mucosal immune response to aeroallergens

被引:0
|
作者
Demoly, P [1 ]
Bousquet, J [1 ]
机构
[1] CHU Montpellier, Hop Arnaud Villeneuve, Inserm U454 IFR3, F-34295 Montpellier 5, France
来源
REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE | 2001年 / 41卷 / 01期
关键词
aeroallergens; IgE; inflammation; antigen presentation; immune response; airway mucosa;
D O I
10.1016/S0335-7457(01)80014-9
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
We do not yet know everything about the different stages whereby respiratory mucosa recognises and processes allergen. In this paper, we will clarify current data regarding aeroallergen presentation and the pathophysiology of respiratory allergies. Allergens can be described as small airborne, soluble antigens capable of inducing an immunoglobulin E (IgE) response. They penetrate the airway epithelium and are taken in by specialised cells capable not only of capturing but also of digesting and then producing them on their surface with molecules from the major histocompatibility complex. It is this network which activates T-lymphocytes (preferentially Th2), thus stimulating B-lymphocytes (which synthesise IgE). Furthermore, the allergens can activate cells through IgE and their receptors. All of the secreted factors (eg,: lipid mediators, chemokines and cytokines) and the expressed molecules (mainly adhesion molecules) result in the recruitment and activation of numerous cells, a source of airway inflammation. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:17 / 22
页数:6
相关论文
共 50 条
  • [1] Evolutionary immune response to conserved domains in parasites and aeroallergens
    Bielory, Brett Phillip
    Mainardi, Timothy
    Rottem, Menachem
    ALLERGY AND ASTHMA PROCEEDINGS, 2013, 34 (01) : 93 - 102
  • [2] Inflammasomes and Mucosal Immune Response
    Elinav, Eran
    Henao-Mejia, Jorge
    Flavell, Richard A.
    INNATE IMMUNITY: RESISTANCE AND DISEASE-PROMOTING PRINCIPLES, 2013, 4 : 48 - +
  • [3] Regulation of the mucosal immune response
    Ernst, PB
    Song, F
    Klimpel, GR
    Haeberle, H
    Bamford, KB
    Crowe, SE
    Ye, G
    Reyes, VE
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 60 (04): : 2 - 9
  • [4] Mucosal Type 2 Innate Lymphoid Cells Are a Key Component of the Allergic Response to Aeroallergens
    Dhariwal, Jaideep
    Cameron, Aoife
    Trujillo-Torralbo, Maria-Belen
    del Rosario, Ajerico
    Bakhsoliani, Eteri
    Paulsen, Malte
    Jackson, David J.
    Edwards, Michael R.
    Rana, Batika M. J.
    Cousins, David J.
    Hansel, Trevor T.
    Johnston, Sebastian L.
    Walton, Ross P.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195 (12) : 1586 - 1596
  • [5] MUCOSAL IMMUNOLOGY A wee immune response
    Bordon, Yvonne
    NATURE REVIEWS IMMUNOLOGY, 2013, 13 (04) : 220 - 220
  • [6] ONTOGENY OF THE MUCOSAL IMMUNE-RESPONSE
    MACDONALD, TT
    SPENCER, J
    SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 1990, 12 (2-3): : 129 - 137
  • [7] The mucosal immune response to laryngopharyngeal reflux
    Rees, Louisa E. N.
    Pazmany, Laszlo
    Gutowska-Owsiak, Danuta
    Inman, Charlotte F.
    Phillips, Anne
    Stokes, Christopher R.
    Johnston, Nikki
    Koufman, Jamie A.
    Postma, Gregory
    Bailey, Michael
    Birchall, Martin A.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (11) : 1187 - 1193
  • [8] INDUCTION OF THE MUCOSAL IMMUNE-RESPONSE
    RUSSELL, MW
    MESTECKY, J
    REVIEWS OF INFECTIOUS DISEASES, 1988, 10 : S440 - S446
  • [9] MUCOSAL IMMUNE-RESPONSE IN TOXOPLASMOSIS
    CHARDES, T
    BOUT, D
    RESEARCH IN IMMUNOLOGY, 1993, 144 (01): : 57 - 60
  • [10] Mucosal immune response to Tropheryma whipplei
    Ring, S
    Schneider, T
    Marth, T
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2003, 293 (01) : 69 - 76