Kinetic model-based factor analysis of dynamic sequences for 82-rubidium cardiac positron emission tomography

被引:10
|
作者
Klein, R. [1 ]
Beanlands, R. S. [1 ]
Wassenaar, R. W. [2 ]
Thorn, S. L. [1 ]
Lamoureux, M. [1 ]
DaSilva, J. N. [1 ]
Adler, A. [3 ]
deKemp, R. A. [1 ]
机构
[1] Univ Ottawa, Inst Heart, Natl Cardiac PET Ctr, Ottawa, ON K1Y 4W7, Canada
[2] Ottawa Hosp, Div Nucl Med, Ottawa, ON K1Y 4E9, Canada
[3] Carleton Univ, Ottawa, ON K1S 5B6, Canada
关键词
factor analysis; cardiac; myocardial perfusion; PET; image analysis; MYOCARDIAL BLOOD-FLOW; PROGNOSTIC VALUE; RB-82; PET; IMAGES; INPUT; DERIVATION; TIME;
D O I
10.1118/1.3438474
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: Factor analysis has been pursued as a means to decompose dynamic cardiac PET images into different tissue types based on their unique temporal signatures to improve quantification of physiological function. In this work, the authors present a novel kinetic model-based (MB) method that includes physiological models of factor relationships within the decomposition process. The physiological accuracy of MB decomposed Rb-82 cardiac PET images is evaluated using simulated and experimental data. Precision of myocardial blood flow (MBF) measurement is also evaluated. Methods: A gamma-variate model was used to describe the transport of Rb-82 in arterial blood from the right to left ventricle, and a one-compartment model to describe the exchange between blood and myocardium. Simulations of canine and rat heart imaging were performed to evaluate parameter estimation errors. Arterial blood sampling in rats and (CO)-C-11 blood pool imaging in dogs were used to evaluate factor and structure accuracy. Variable infusion duration studies in canine were used to evaluate MB structure and global MBF reproducibility. All results were compared to a previously published minimal structure overlap (MSO) method. Results: Canine heart simulations demonstrated that MB has lower root-mean-square error (RMSE) than MSO for both factor (0.2% vs 0.5%, p<0.001 MB vs MSO, respectively) and structure (3.0% vs 4.7%, p<0.001) estimations, as with rat heart simulations (factors: 0.2% vs 0.9%, p<0.001 and structures: 3.0% vs 6.7%, p<0.001). MB blood factors compared to arterial blood samples in rats had lower RMSE than MSO (1.6% vs 2.2%, p=0.025). There was no difference in the RMSE of blood structures compared to a (CO)-C-11 blood pool image in dogs (8.5% vs 8.8%, p=0.23). Myocardial structures were more reproducible with MB than with MSO (RMSE=3.9% vs 6.2%, p<0.001), as were blood structures (RMSE=4.9% vs 5.6%, p=0.006). Finally, MBF values tended to be more reproducible with MB compared to MSO (CV=10% vs 18%, p=0.16). The execution time of MB was, on average, 2.4 times shorter than MSO (p<0.001) due to fewer free parameters. Conclusions: Kinetic model-based factor analysis can be used to provide physiologically accurate decomposition of Rb-82 dynamic PET images, and may improve the precision of MBF quantification. (C) 2010 American Association of Physicists in Medicine. [DOI: 10.1118/1.3438474]
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页码:3995 / 4010
页数:16
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