m-Coumaric acid attenuates non-catalytic protein glycosylation in the retinas of diabetic rats

被引：11

作者：

Moselhy, Said Salama ^{[1
,2
,3
]}

Razvi, Syed Shoeb ^{[4
]}

ALshibili, Fawzia A. ^{[4
]}

Kuerban, Abudukadeer ^{[4
]}

Hasan, Mohammed Nihal ^{[4
]}

Balamash, Khadijah Saeed ^{[4
]}

Huwait, Etimad A. ^{[4
]}

Abdulaal, Wesam H. ^{[4
]}

Al-Ghamdi, Maryam A. ^{[4
]}

Kumosani, Taha A. ^{[2
,5
]}

Abulnaja, Khalid Omar ^{[1
,2
]}

Al-Malki, Abdulrahman L. ^{[1
,2
]}

Asami, Tadao ^{[4
,6
]}

Ismail, Iman M. ^{[7
]}

机构：

[1] King Abdulaziz Univ, King Fand Med Res Ctr, Bioact Nat Prod Res Grp, Biochem Dept,Fac Sci, Jeddah 21589, Saudi Arabia

[2] King Abdulaziz Univ, King Fand Med Res Ctr, Expt Biochem Unit, Jeddah 21589, Saudi Arabia

[3] Ain Shams Univ, Fac Sci, Dept Biochem, Cairo, Egypt

[4] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah 21589, Saudi Arabia

[5] King Abdulaziz Univ, King Fand Med Res Ctr, Prod Bioprod Ind Applicat Res Grp, Biochem Dept,Fac Sci, Jeddah 21589, Saudi Arabia

[6] Univ Tokyo, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

[7] King Abdulaziz Univ, Fac Home Ecin, Dept Nutr, Jeddah, Saudi Arabia

来源：

JOURNAL OF PESTICIDE SCIENCE | 2018年 / 43卷 / 3-4期

关键词：

diabetic rats; AGEs; HCA; m-coumaric acid; hyperglycemia; retinopathy; ADVANCED GLYCATION ENDPRODUCTS; ALDOSE REDUCTASE; IN-VITRO; HYDROXYCINNAMIC ACID; ABNORMALITIES; ANTIOXIDANT; RETINOPATHY; PRODUCTS; STRESS; GROWTH;

D O I：

10.1584/jpestics.D17-091

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

In this study, we investigated the inhibitory effects of m-coumaric acid on the glycosylation of proteins in the retinas of diabetic rats. Male rats were divided into two main groups, Group I (normal control) and Group II (diabetic); Group II was further divided into four subgroups: Group Ha (diabetic control), Group IIb (diabetic rats were given m-coumaric acid orally [150 mg/kg, body weight (bw)/day]), Group IIc (diabetic rats were given HCA m-coumaric acid orally [300 mg/kg bw/day]), and Group lid (diabetic rats were given insulin 110 units/kg bw/day]) as a positive control). The treatment lasted for six weeks, and the data obtained suggested that m-coumaric acid reduced glucose and glycated hemoglobin levels, which further decreased the formation of glucose-derived advanced glycation end products. Hence, it protected the tissues from the detrimental effects of hyperglycemia and enhanced antioxidant activity. In conclusion, m-coumaric acid could be a potential candidate to prevent the onset and progression of retinopathy in diabetic patients. (C) Pesticide Science Society of Japan

引用

页码：180 / 185

页数：6

共 5 条

[1] p-Coumaric acid attenuates high-fat diet-induced oxidative stress and nephropathy in diabetic rats
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[2] A single amino acid mutation affects elicitor and expansins-like activities of ceratoplatanin, a non-catalytic fungal protein
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Martellini, Federica
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[3] Low protein diet inhibits uric acid synthesis and attenuates renal damage in streptozotocin-induced diabetic rats
Ran, J.
Ma, J.
Liu, Y.
Tan, R.
Liu, H.
Lao, G.
DIABETOLOGIA, 2012, 55 : S457 - S457
[4] Low Protein Diet Inhibits Uric Acid Synthesis and Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats
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Ma, Jing
Liu, Yan
Tan, Rongshao
Liu, Houqiang
Lao, Gancheng
JOURNAL OF DIABETES RESEARCH, 2014, 2014
[5] COMPARISON OF URINARY EXCRETION OF KETONE BODIES, NON-PROTEIN NITROGEN, CITRIC ACID AND GLUCOSE IN ALLOXAN DIABETIC AND DEPANCREATIZED RATS
BEATTY, CH
PETERSON, RD
AMERICAN JOURNAL OF PHYSIOLOGY, 1955, 183 (02): : 325 - 330

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