PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade

被引：91

作者：

Hirsch, Laure ^{[1
]}

Zitvogel, Laurence ^{[2
]}

Eggermont, Alexander ^{[3
]}

Marabelle, Aurelien ^{[1
,2
]}

机构：

[1] Univ Paris Saclay, Dept Innovat Therapeut & Essais Precoces, Gustave Roussy, F-94805 Villejuif, France

[2] Univ Paris Saclay, INSERM, U1015, Gustave Roussy, F-94805 Villejuif, France

[3] Univ Paris Saclay, Gustave Roussy, F-94805 Villejuif, France

来源：

BRITISH JOURNAL OF CANCER | 2019年 / 120卷 / 01期

关键词：

OPEN-LABEL; NIVOLUMAB; PEMBROLIZUMAB; MULTICENTER; SAFETY; DOCETAXEL;

D O I：

10.1038/s41416-018-0294-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clinical trials have now identified over 30 cancer histotypes with sensitivity to anti-PD-(L)1 therapies. It is the first time in oncology that a class of drugs has demonstrated such a wide spectrum of activity in monotherapy. This subgroup of cancers ('PD-Lomas') is driving the clinical research strategies for the next generation of combination immunotherapy.

引用

页码：3 / 5

页数：3

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