GingerMechanism of action in chemotherapy-induced nausea and vomiting: A review

被引:98
|
作者
Marx, Wolfgang [1 ,2 ]
Ried, Karin [2 ]
McCarthy, Alexandra L. [3 ,4 ]
Vitetta, Luis [5 ]
Sali, Avni [2 ]
McKavanagh, Daniel [6 ]
Isenring, Liz [1 ,7 ,8 ]
机构
[1] Univ Queensland, Ctr Dietet Res, St Lucia, Qld, Australia
[2] Natl Inst Integrat Med, Melbourne, Vic, Australia
[3] Queensland Univ Technol, Princess Alexandra Hosp, Div Canc Serv, Brisbane, Qld, Australia
[4] Queensland Univ Technol, Inst Biomed Innovat, Brisbane, Qld, Australia
[5] Princess Alexandra Hosp, Sch Med, Ctr Integrat Clin & Mol Med, Woolloongabba, Qld, Australia
[6] Princess Alexandra Hosp, Oncol & Haematol Unit, Woolloongabba, Qld, Australia
[7] Princess Alexandra Hosp, Dept Nutr & Dietet, Woolloongabba, Qld, Australia
[8] Bond Univ, Hlth Sci & Med, Gold Coast, Qld, Australia
基金
英国医学研究理事会;
关键词
Ginger; nausea; chemotherapy; CINV; vomiting; GINGER ZINGIBER-OFFICINALE; SLOW-WAVE DYSRHYTHMIAS; MOTION SICKNESS; CLINICAL-TRIALS; CROSSOVER TRIAL; INDUCED EMESIS; MOTILITY; RATS; EXTRACT; PLACEBO;
D O I
10.1080/10408398.2013.865590
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Despite advances in antiemetic therapy, chemotherapy-induced nausea and vomiting (CINV) still poses a significant burden to patients undergoing chemotherapy. Nausea, in particular, is still highly prevalent in this population. Ginger has been traditionally used as a folk remedy for gastrointestinal complaints and has been suggested as a viable adjuvant treatment for nausea and vomiting in the cancer context. Substantial research has revealed ginger to possess properties that could exert multiple beneficial effects on chemotherapy patients who experience nausea and vomiting. Bioactive compounds within the rhizome of ginger, particularly the gingerol and shogaol class of compounds, interact with several pathways that are directly implicated in CINV in addition to pathways that could play secondary roles by exacerbating symptoms. These properties include 5-HT3, substance P, and acetylcholine receptor antagonism; antiinflammatory properties; and modulation of cellular redox signaling, vasopressin release, gastrointestinal motility, and gastric emptying rate. This review outlines these proposed mechanisms by discussing the results of clinical, in vitro, and animal studies both within the chemotherapy context and in other relevant fields. The evidence presented in this review indicates that ginger possesses multiple properties that could be beneficial in reducing CINV.
引用
收藏
页码:141 / 146
页数:6
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