Persuasive health messages can be framed to emphasize the benefits of adopting a health behavior (gains) or the risks of not adopting it (losses). This study examined the effects of message framing on beliefs, attitudes, and behaviors relevant to cigarette smoking. in video presentations about tobacco smoking, visual images and auditory voiceover content were framed either as gains or losses, yielding 4 message conditions. Undergraduates (N = 437) attending a public university in New England were assigned randomly to view one of these messages. Gain-framed messages about smoking in visual and auditory modalities shined smoking-related beliefs, attitudes, and behaviors in the direction of avoidance and cessation, Health-communication experts, when promoting prevention behaviors like smoking avoidance or cessation, may wish to diverge from the tradition of using loss-framed messages and fear appeals in this domain, and instead consider using gain-framed appeals that present the advantages of not smoking.