Synthesis of conformationally constrained α-amino acid derivatives containing bicyclo[2.2.2] unit via the Diels-Alder and Suzuki-Miyaura cross-coupling reactions as key steps

被引：0

作者：

Kotha, Sambasivarao ^{[1
]}

Meshram, Milind ^{[1
]}

Muthusamy, Gopinathan ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2015年 / 54卷 / 04期

关键词：

Bicyclic alpha-amino acid derivatives; glycine equivalent; anthracene derivatives; Diels-Alder reaction; Suzuki-Miyaura cross-coupling reaction; Buchwald ligand; 9-SUBSTITUTED ANTHRACENES; 2-ACETAMIDOACRYLATE; BROMINATION; METATHESIS; DIVERSITY;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple route to synthesize conformationally constrained a-amino acid (AAA) derivatives containing bicyclo[2.2.2]octane ring-system has been devised. Diels-Alder reaction is chosen to assemble highly constrained AAA derivatives and the scope of the methodology is further expanded by Suzuki-Miyaura cross-coupling reaction with various boronic acids.

引用

页码：505 / 513

页数：9

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