Procalcitonin in detecting neonatal nosocomial sepsis

被引：78

作者：

Auriti, Cinzia ^{[1
]}

Fiscarelli, Ersilia ^{[2
]}

Ronchetti, Maria Paola ^{[1
]}

Argentieri, Marta ^{[2
]}

Marrocco, Gabriella ^{[1
]}

Quondamcarlo, Anna ^{[1
]}

Seganti, Giulio ^{[1
]}

Bagnoli, Francesco ^{[3
]}

Buonocore, Giuseppe ^{[3
]}

Serra, Giovanni ^{[4
]}

Bacolla, Gianfranco ^{[5
]}

Mastropasqua, Savino ^{[6
]}

Mari, Annibale ^{[7
]}

Corchia, Carlo ^{[1
]}

Prencipe, Giusi ^{[1
]}

Piersigilli, Fiammetta ^{[1
]}

Rava, Lucilla ^{[8
]}

Di Ciommo, Vincenzo ^{[8
]}

机构：

[1] Bambino Gesu Pediat Hosp, Neonatal Intens Care Unit, I-00165 Rome, Italy

[2] Bambino Gesu Pediat Hosp, Dept Lab, I-00165 Rome, Italy

[3] Le Scotte Univ Hosp, Neonatal Intens Care Unit, Siena, Italy

[4] Giannina Gaslini Pediat Hosp, Neonatal Intens Care Unit, Genoa, Italy

[5] Burlo Garofolo Res Inst, Neonatal Intens Care Unit, Trieste, Italy

[6] Di Venere Hosp, Neonatal Intens Care Unit, Bari, Italy

[7] Gen Hosp, Neonatal Intens Care Unit, Cosenza, Italy

[8] Bambino Gesu Pediat Hosp, Epidemiol Unit, I-00165 Rome, Italy

来源：

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION | 2012年 / 97卷 / 05期

关键词：

INFECTION; INFANTS;

D O I：

10.1136/fetalneonatal-2010-194100

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective To investigate the accuracy of procalcitonin (PCT) as a diagnostic marker of nosocomial sepsis (NS) and define the most accurate cut-off to distinguish infected from uninfected neonates. Setting Six neonatal intensive care units (NICUs). Patients 762 neonates admitted to six NICUs during a 28-month observational study for whom at least one serum sample was taken on admission. Main outcome measures Positive and negative predictive values at different PCT cut-off levels. Results The overall probability of an NS was doubled or more if PCT was >0.5 ng/ml. In very-low-birth-weight (VLBW) infants, a cut-off of >2.4 ng/ml gave a positive predictive value of NS near to 50% with a probability of a false-positive diagnosis of NS in about 10% of the patients. Conclusions In VLBW neonates, a serum PCT value >2.4 ng/ml prompts early empirical antibiotic therapy, while in normal-birth-weight infants, a PCT value <= 2.4 ng/ml carries a low risk of missing an NS.

引用

页码：F368 / F370

页数：3

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