Flueggeacosines A-C, Dimeric Securinine-Type Alkaloid Analogues with Neuronal Differentiation Activity from Flueggea suffruticosa

被引：32

作者：

Wu, Zhen-Long ^{[1
,2
]}

Huang, Xiao-Jun ^{[1
,2
]}

Xu, Ming-Tao ^{[1
,2
]}

Ma, Xuanyue ^{[2
]}

Li, Liuren ^{[2
]}

Shi, Lei ^{[2
]}

Wang, Wen-Jing ^{[2
]}

Jiang, Ren-Wang ^{[1
,2
]}

Ye, Wen-Cai ^{[1
,2
]}

Wang, Ying ^{[1
,2
]}

机构：

[1] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 23期

基金：

中国国家自然科学基金;

关键词：

INDOLIZIDINE ALKALOIDS; ABSOLUTE-CONFIGURATION; SKELETON;

D O I：

10.1021/acs.orglett.8b03432

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Flueggeacosines A-C (1-3), three dimeric securinine-type alkaloid analogues with unprecedented skeletons, were isolated from Flueggea suffruticosa. Compounds 1 and 2 are the first examples of C-3 C-15' connected dimeric securininetype alkaloids. Compound 3 is an unprecedented heterodimer of securinine-type and benzoquinolizidine alkaloids. Biosynthetic pathways for 1-3 were proposed on the basis of the coexisting alkaloid monomers as the precursors. Compound 2 exhibited significant activity in promoting neuronal differentiation of Neuro-2a cells.

引用

页码：7703 / 7707

页数：5