Introduction: Crashes involving roadway objects and animals can cause severe injuries and property damages and are a major concern for the traveling public, state transportation agencies, and the automotive industry. This project involved an in-depth investigation of such crashes based on the second Strategic Highway Research Program (SHRP 2) Naturalistic Driving Study (NDS) data including detailed information and videos about 2,689 events. Methods: The research team conducted a variety of logistic regression analyses, complemented by Support Vector Machine (SVM) analyses and detailed case studies. Results: The logistic regression results indicated that driver behavior/errors, involvement of secondary tasks, roadway characteristics, lighting condition, and pavement surface condition are among the factors that contributed significantly to the occurrence and/or increased severity outcomes of crashes involving roadway objects and animals. Among these factors, improper turning movements (odds ratio = 88), avoiding animal or other vehicle (odds ratio = 38), and reaching/moving object in vehicle (odds ratio = 29) particularly increased the odds of crash occurrence. Factors such as open country roadways, sign/signal violation, unfamiliar with roadway, fatigue/drowsiness, and speeding significantly increased the severity outcomes when such crashes occurred. The sensitivity analysis of the three SVM classifiers confirmed that driver behavior/errors, critical speed, struck object type, and reaction time were major factors affecting the occurrence and severity outcomes of events involving roadway objects and animals. Published by Elsevier Ltd.