AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides

被引：33

作者：

Acevedo-Jake, Amanda ^{[1
]}

Ball, Andrew T. ^{[1
]}

Galli, Marzia ^{[1
]}

Kukwikila, Mikiembo ^{[1
]}

Denis, Mathieu ^{[1
]}

Singleton, Daniel G. ^{[2
]}

Tavassoli, Ali ^{[1
]}

Goldup, Stephen M. ^{[1
]}

机构：

[1] Univ Southampton, Chem, Southampton SO17 1BJ, Hants, England

[2] Univ Southampton, Sch Chem, ATDBio Ltd, Southampton SO17 1BJ, Hants, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2020年 / 142卷 / 13期

基金：

欧洲研究理事会; 英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

ARTIFICIAL MOLECULAR MACHINES; LASSO PEPTIDES; DRUG-DELIVERY; DNA; GENE; ROTAXANES; CATENANES; NANOSTRUCTURES; POLYROTAXANES; MACROCYCLE;

D O I：

10.1021/jacs.0c01670

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

引用

页码：5985 / 5990

页数：6

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