A high-performance lab-on-a-chip liquid sensor employing surface acoustic wave resonance

被引：17

作者：

Kustanovich, K. ^{[1
]}

Yantchev, V. ^{[1
]}

Kirejev, V. ^{[1
]}

Jeffries, G. D. M. ^{[1
]}

Lobovkina, T. ^{[1
]}

Jesorka, A. ^{[1
]}

机构：

[1] Chalmers Univ Technol, Biophys Technol Lab, Dept Chem & Chem Engn, Kemivagen 10, S-41296 Gothenburg, Sweden

来源：

JOURNAL OF MICROMECHANICS AND MICROENGINEERING | 2017年 / 27卷 / 11期

关键词：

sensor; microfluidics; surface acoustic waves; resonance; integration; VESICLE FUSION; BIOSENSOR; FREQUENCY; MEMBRANES; SYSTEMS; DESIGN; DEVICE;

D O I：

10.1088/1361-6439/aa8f21

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We demonstrate herein a new concept for lab-on-a-chip in-liquid sensing, through integration of surface acoustic wave resonance (SAR) in a one-port configuration with a soft polymer microfluidic delivery system. In this concept, the reflective gratings of a one-port surface acoustic wave (SAW) resonator are employed as mass loading-sensing elements, while the SAW transducer is protected from the measurement environment. We describe the design, fabrication, implementation, and characterization using liquid medium. The sensor operates at a frequency of 185 MHz and has demonstrated a comparable sensitivity to other SAW in-liquid sensors, while offering quality factor (Q) value in water of about 250, low impedance and fairly low susceptibility to viscous damping. For proof of principle, sensing performance was evaluated by means of binding 40 nm neutravidin-coated SiO2 nanoparticles to a biotin-labeled lipid bilayer deposited over the reflectors. Frequency shifts were determined for every step of the affinity assay. Demonstration of this integrated technology highlights the potential of SAR technology for in-liquid sensing.

引用

页数：9