The structural and biological properties of hydroxyapatite-modified titanate nanowire scaffolds

被引:84
|
作者
Zhao, Haixin [1 ]
Dong, Wenjun [1 ,2 ]
Zheng, Yingying [1 ]
Liu, Aiping [1 ]
Yao, Juming [1 ]
Li, Chaorong [1 ]
Tang, Weihua [1 ]
Chen, Benyong [1 ]
Wang, Ge [2 ]
Shi, Zhan [3 ]
机构
[1] Zhejiang Sci Tech Univ, Ctr Optoelect Mat & Devices, Key Lab Adv Text Mat & Mfg Technol,Minist Educ, Ctr Nanosci & Noanotechnol,Engn Res Ctr Eco Dying, Hangzhou 310018, Zhejiang, Peoples R China
[2] Univ Sci & Technol Beijing, Sch Mat Sci & Engn, Beijing 100083, Peoples R China
[3] Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Scaffold; Hydroxyapatite; Titanate nanowire; Biomaterial; COATINGS; BIOMATERIALS; TITANIUM; ELECTRODEPOSITION; APATITE; LUMINESCENT; FABRICATION; STABILITY; GROWTH;
D O I
10.1016/j.biomaterials.2011.04.083
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Hydroxyapatite-modified titanate nanowire scaffolds as alternative materials for tissue engineering have been developed via a titanate nanowire matrix assisted electrochemical deposition method. The macroporous titanate nanowire matrix on Ti metal was fabricated by a hydrothermal method, and then followed by an electrochemical synthesis of hydroxyapatite nanoparticles on titanate nanowire. The incorporation of titanate nanowire matrix with high oriented hydroxyapatite nanoparticles generates hierarchical scaffolds with highly osteogenic, structural integrity and excellent mechanical performance. As-prepared porous three dimensional interconnected hydroxyapatite-modified titanate nanowire scaffolds, mimicking the nature's extracellular matrix, could provide a suitable microenvironment for tissue cell ingrowth and differentiation. The ceramic titanate nanowire core with HA nanoparticle sheath structure displays superhydrophilicity, which facilitates the cell attachment and proliferation, and induces the in vitro tissue-engineered bone. Human osteoblast-like MG63 cells were cultured on the hydroxyapatite-modified titanate nanowire scaffolds, and the results showed that the scaffolds highly promote the bioactivity, osteoconductivity and osteoblast differentiation. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5837 / 5846
页数:10
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