Advances in the knowledge of breast cancer stem cells. A review

被引：12
|
作者：
Schwarz-Cruz y Celis, Angela [1 ,2 ]
Espinosa, Magali [1 ]
Maldonado, Vilma [1 ]
Melendez-Zajgla, Jorge [1 ]
机构：
[1] Natl Inst Genom Med, Funct Genom Lab, Perifer Sur 4809 Col Arenal Tepepan, Mexico City, DF, Mexico
[2] Univ Nacl Autonoma Mexico, Mexico City 04510, DF, Mexico
来源：
HISTOLOGY AND HISTOPATHOLOGY | 2016年 / 31卷 / 06期
关键词：
Breast cancer; Cancer stem cells; Breast cancer stem cells; Markers; Therapeutic resistance; EPITHELIAL-MESENCHYMAL TRANSITION; ACUTE MYELOID-LEUKEMIA; SIDE POPULATION CELLS; ALDEHYDE DEHYDROGENASE; INITIATING CELLS; DIFFERENTIAL EXPRESSION; COLORECTAL-CANCER; CD133(+) CELLS; MARKERS CD44; CLAUDIN-LOW;
D O I：
10.14670/HH-11-718
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis and the development of drug resistance. These findings make the need to find the distinguishing blend of markers that can recognize only BCSCs of the utmost importance in order to be able to design new targeted therapies. This review will summarize BCSCs' main features as well as the cell surface markers that are currently used to identify them.
引用
收藏
页码：601 / 612
页数：12
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