Long non-coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1

被引：4
|
作者：
Zhou, Taicheng [1 ,2 ]
Wu, Lili [3 ]
Zong, Zhen [4 ]
Ma, Ning [1 ,2 ]
Li, Yingru [1 ,2 ]
Jiang, Zhipeng [1 ,2 ]
Wang, Qirui [5 ]
Chen, Shuang [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gastroenterol Surg, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, 26 Yuancun Erheng Rd, Guangzhou 510655, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 6, Hernia Ctr, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, 26 Yuancun Erheng Rd, Guangzhou 510655, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Dept Ultrasonol, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China
[4] Nanchang Univ, Dept Gastroenterol Surg, Affiliated Hosp 2, Nanchang 510655, Jiangxi, Peoples R China
[5] Southern Med Univ, Sch Tradit Chinese Med, Dept Mol Biol, State Adm Tradit Chinese Med Peoples Republ China, 1838 North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China
来源：
ONCOLOGY LETTERS | 2020年 / 19卷 / 02期
关键词：
colon cancer; long non-coding RNA mortal obligate RNA transcript; transforming growth factor beta 1; prognosis;
D O I：
10.3892/ol.2019.11189
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Long non-coding (lnc)RNA mortal obligate RNA transcript (MORT) is inhibited in numerous types of cancer in humans, indicating its role as a tumor suppressor. The present study demonstrated downregulation of lncRNA MORT in the tumor tissues of patients with colon cancer. The expression of MORT in tumor tissues was linearly associated with its expression levels in plasma. Low MORT expression was associated with low overall survival rate. Moreover, the overexpression of MORT resulted in decreased, whereas treatment with transforming growth factor beta 1 (TGF-beta 1) resulted in increased, invasion and migration rates of colon cancer cells. In addition, TGF-beta 1 treatment attenuated the inhibitory effect of MORT overexpression on the invasion and migration rates of colon cancer cells. The overexpression of MORT inhibited TGF-beta 1 expression in colon cancer cells, whereas treatment with TGF-beta 1 failed to affect the expression of the lncRNA. Therefore, it is postulated that MORT inhibits invasion and migration colon cancer cells by inactivating TGF-beta 1.
引用
收藏
页码：1131 / 1136
页数：6
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