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- [6] Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2006, 60 (11) : 1343 - 1356