Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination

被引：5
|
作者：
Wales, J. [1 ]
Andreakols, E. [1 ]
Feldmann, M. [1 ]
Foxwell, B. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Kennedy Inst Rheumatol, London W6 8LH, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷
关键词：
interferon regulatory factor (IRF); molecular vaccine adjuvant; myeloid differentiation factor 88 (MyD88); nuclear factor kappa B-inducing kinase (NIK); suppressor of cytokine signalling 1 (SOCS1); Toll/interleukin-1 receptor domain-containing adaptor protein inducing interferon beta (TRIF);
D O I：
10.1042/BST0351501
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
PRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellular signalling networks would allow for greater specificity and reduced systemic toxicity. The present review examines the successes seen with overexpression or repression of PIRR signalling molecules.
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页码：1501 / 1503
页数：3
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